Postoperative delirium and changes in the blood–brain barrier, neuroinflammation, and cerebrospinal fluid lactate: a prospective cohort study

2022/02/08 by Jennifer Taylor, Margaret Parker, Cameron Casey +10 · 25 citations
Medicine · #Intensive Care Unit Cognitive Disorders #Thermal Regulation in Medicine #Enhanced Recovery After Surgery

paper · doi:10.1016/j.bja.2022.01.005

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• Genome-wide DNA methylation analysis of post-operative delirium with brain, blood, saliva, and buccal samples from neurosurgery patients. [europepmc]
• Reactive oxygen species contribute to delirium-like behavior by activating CypA/MMP9 signaling and inducing blood-brain barrier impairment in aged mice following anesthesia and surgery. [europepmc]
• Nomogram to predict postoperative cognitive dysfunction in elderly patients undergoing gastrointestinal tumor resection. [europepmc]
• Postoperative delirium, neuroinflammation, and influencing factors of postoperative delirium: A review. [europepmc]
• Postoperative C-Reactive Protein Predicts Postoperative Delirium in Colorectal Cancer Following Surgery. [europepmc]
• Research progress on perioperative blood-brain barrier damage and its potential mechanism. [europepmc]
• A predictive scoring system for postoperative delirium in the elderly patients with intertrochanteric fracture. [europepmc]
• Resolution of elevated interleukin-6 after surgery is associated with return of normal cognitive function. [europepmc]
• High preoperative blood oxaloacetate and 2-aminoadipic acid levels are associated with postoperative delayed neurocognitive recovery. [europepmc]
• Role of Blood-Brain Barrier Dysfunction in Delirium following Non-cardiac Surgery in Older Adults. [europepmc]
• Delirium is associated with loss of feedback cortical connectivity. [europepmc]
• Exploring the Pathophysiology of Delirium: An Overview of Biomarker Studies, Animal Models, and Tissue-Engineered Models. [europepmc]
• Taming Postoperative Delirium with Dexmedetomidine: A Review of the Therapeutic Agent's Neuroprotective Effects following Surgery. [europepmc]
• The Effects of Appropriate Perioperative Exercise on Perioperative Neurocognitive Disorders: a Narrative Review. [europepmc]
• Effect of Intraoperative Intravenous Lidocaine on Postoperative Delirium in Elderly Patients with Hip Fracture: A Prospective Randomized Controlled Trial. [europepmc]
• Impact of Preoperative Sleep Disturbances on Postoperative Delirium in Patients with Intracranial Tumors: A Prospective, Observational, Cohort Study. [europepmc]
• Emerging diagnostic markers and therapeutic targets in post-stroke hemorrhagic transformation and brain edema. [europepmc]
• From the Mind to the Spine: The Intersecting World of Alzheimer's and Osteoporosis. [europepmc]
• Association between preoperative albumin levels and postoperative delirium in geriatric hip fracture patients. [europepmc]
• Impact of intraoperative dexmedetomidine on postoperative delirium and pro-inflammatory cytokine levels in elderly patients undergoing thoracolumbar compression fracture surgery: A prospective, randomized, placebo-controlled clinical trial. [europepmc]
• Associations of serum lactate and lactate clearance with delirium in the early stage of ICU: a retrospective cohort study of the MIMIC-IV database. [europepmc]
• Association between surgical admissions, cognition, and neurodegeneration in older people: a population-based study from the UK Biobank. [europepmc]
• Serum Albumin Level at Intensive Care Unit Admission and Delirium Duration and Severity in Critically Ill Adults. [europepmc]
• Advancing Delirium Treatment Trials in Older Adults: Recommendations for Future Trials From the Network for Investigation of Delirium: Unifying Scientists (NIDUS). [europepmc]
• Intranasal Insulin Diminishes Postoperative Delirium and Elevated Osteocalcin and Brain Derived Neurotrophic Factor in Older Patients Undergoing Joint Replacement: A Randomized, Double-Blind, Placebo-Controlled Trial. [europepmc]