Association of intraoperative changes in brain-derived neurotrophic factor and postoperative delirium in older adults

2017/03/24 by J. Wyrobek, Julie Wyrobek, Andrew Laflam +19 · 58 citations
Medicine · Neuroscience · #Anesthesia #Anesthesia and Neurotoxicity Research #Brain-derived neurotrophic factor #Cancer, Stress, Anesthesia, and Immune Response #Confidence interval #Delirium #Intensive Care Unit Cognitive Disorders #Internal medicine #Interquartile range #Medicine #Neurotrophic factors #Odds ratio #Prospective cohort study #Psychiatry

paper · pdf · doi:10.1093/bja/aex103

published in British Journal of Anaesthesia 119(2), 324-332 (Elsevier BV)

openalex publication_date 2017/03/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Citations

• Clarifying Confusion: The Confusion Assessment Method
• Delirium After Spine Surgery in Older Adults: Incidence, Risk Factors, and Outcomes

Cited by

• Abnormal composition of gut microbiota contributes to delirium-like behaviors after abdominal surgery in mice. [europepmc]
• Pre-operative biomarkers and imaging tests as predictors of post-operative delirium in non-cardiac surgical patients: a systematic review. [europepmc]
• Histone H3K9 Trimethylation Downregulates the Expression of Brain-Derived Neurotrophic Factor in the Dorsal Hippocampus and Impairs Memory Formation During Anaesthesia and Surgery. [europepmc]
• Association of neuronal repair biomarkers with delirium among survivors of critical illness. [europepmc]
• Muscle Injury Induces Postoperative Cognitive Dysfunction. [europepmc]
• Plasma and Cerebrospinal Fluid Candidate Biomarkers of Neonatal Encephalopathy Severity and Neurodevelopmental Outcomes. [europepmc]
• The relationship between DNA methylation in neurotrophic genes and age as evidenced from three independent cohorts: differences by delirium status. [europepmc]
• Perioperative neurocognitive dysfunction: thinking from the gut? [europepmc]
• Pathomechanisms of Non-Traumatic Acute Brain Injury in Critically Ill Patients. [europepmc]
• Preoperative Prognostic Nutritional Index Value is Related to Postoperative Delirium in Elderly Patients After Noncardiac Surgery: A Retrospective Cohort Study. [europepmc]
• The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders. [europepmc]
• BDNF Therapeutic Mechanisms in Neuropsychiatric Disorders. [europepmc]
• Higher serum PGE2 is a predicative biomarker for postoperative delirium following elective orthopedic surgery in elderly patients. [europepmc]
• Alfaxalone anaesthesia increases brain derived neurotrophic factor levels and preserves postoperative cognition by activating pregnane-X receptors: an in vitro study and a double blind randomised controlled trial. [europepmc]
• Postoperative delirium, neuroinflammation, and influencing factors of postoperative delirium: A review. [europepmc]
• Biomarkers of delirium risk in older adults: a systematic review and meta-analysis. [europepmc]
• Serum Biomarkers of a Pro-Neuroinflammatory State May Define the Pre-Operative Risk for Postoperative Delirium in Spine Surgery. [europepmc]
• Electrical Activity Changes and Neurovascular Unit Markers in the Brains of Patients after Cardiac Surgery: Effects of Multi-Task Cognitive Training. [europepmc]
• Alterations in Neurotrophins in Alcohol-Addicted Patients during Alcohol Withdrawal. [europepmc]
• Dexmedetomidine administration as a possible cognitive enhancer through increasing the level of brain-derived neurotrophic factors in surgical patients: a systematic review and meta-analysis. [europepmc]
• Common molecular and pathophysiological underpinnings of delirium and Alzheimer's disease: molecular signatures and therapeutic indications. [europepmc]
• Association Between Plasma Amyloid-Beta 42 Ratio and Postoperative Delirium in Elderly Patients Undergoing Major Abdominal Surgery: Secondary Analysis of a Randomized Controlled Trial. [europepmc]
• The Causal Relationship Between Neurotrophic Factors and Delirium: A Mendelian Randomization Study. [europepmc]
• Association of Central Nervous System-Related Biomarkers With Hospital Delirium in Patients With Respiratory Failure in the ICU. [europepmc]
• GABA B receptor activation contributes to post-surgery cognitive impairments in mice by inducing hippocampal BDNF hypermethylation. [europepmc]