Sciatica: a review of history, epidemiology, pathogenesis, and the role of epidural steroid injection in management

2007/08/18 by M.A. Stafford, Mai Stafford, P. Peng +3 · 27 citations
Medicine · #Anesthesia and Pain Management #Epidemiology #Incidence (geometry) #Internal medicine #Low back pain #Lumbar #Medicine #Musculoskeletal pain and rehabilitation #Natural history #Pathology #Physical therapy #Radicular pain #Sciatica #Spine and Intervertebral Disc Pathology #Surgery

paper · pdf · doi:10.1093/bja/aem238

openalex publication_date 2007/08/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Cited by

• A systematic review of genome-wide association studies for pain, nociception, neuropathy, and pain treatment responses
• The Efficacy of Acupuncture for the Treatment of Sciatica: A Systematic Review and Meta-Analysis
• Influence of cytokine inhibitors on concentration and activity of MMP-1 and MMP-3 in disc herniation. [europepmc]
• A randomized clinical trial of the effectiveness of mechanical traction for sub-groups of patients with low back pain: study methods and rationale. [europepmc]
• Does norepinephrine influence pain behavior mediated by dorsal root ganglia?: a pilot study. [europepmc]
• PRECISE - pregabalin in addition to usual care for sciatica: study protocol for a randomised controlled trial. [europepmc]
• Outcome prediction in chronic unilateral lumbar radiculopathy: prospective cohort study. [europepmc]
• Acupuncture for treating sciatica: a systematic review protocol. [europepmc]
• The Efficacy of Acupuncture for the Treatment of Sciatica: A Systematic Review and Meta-Analysis. [europepmc]
• Non-steroidal anti-inflammatory drugs for sciatica. [europepmc]
• Genome-Wide Meta-Analysis of Sciatica in Finnish Population. [europepmc]
• Surgical versus conservative treatment for lumbar disc herniation: a prospective cohort study. [europepmc]
• Nonsurgical Treatment Choices by Individuals with Lumbar Intervertebral Disc Herniation in the United States: Associations with Long-term Outcomes. [europepmc]
• Cost-effectiveness of combination therapy (Mechanical Diagnosis and Treatment and Transforaminal Epidural Steroid Injections) among patients with an indication for a Lumbar Herniated Disc surgery: Protocol of a randomized controlled trial. [europepmc]
• Therapeutic Efficacy and the Impact of the "Dose" Effect of Acupuncture to Treat Sciatica: A Randomized Controlled Pilot Study. [europepmc]
• Role of transforaminal epidural injections or selective nerve root blocks in the management of lumbar radicular syndrome - A narrative, evidence-based review. [europepmc]
• Clinical Presentations of Lumbar Disc Degeneration and Lumbosacral Nerve Lesions. [europepmc]
• Extra-spinal sciatica and sciatica mimics: a scoping review. [europepmc]
• Physical Therapy Referral From Primary Care for Acute Back Pain With Sciatica : A Randomized Controlled Trial. [europepmc]
• Resting-State Magnetoencephalography Reveals Neurobiological Bridges Between Pain and Cognitive Impairment. [europepmc]
• Herpes zoster in patients with sciatica. [europepmc]
• Microarray analysis reveals an inflammatory transcriptomic signature in peripheral blood for sciatica. [europepmc]
• Needling Interventions for Sciatica: Choosing Methods Based on Neuropathic Pain Mechanisms-A Scoping Review. [europepmc]
• Urine Metabolomics Profiling of Lumbar Disc Herniation and its Traditional Chinese Medicine Subtypes in Patients Through Gas Chromatography Coupled With Mass Spectrometry. [europepmc]
• Platelet Rich Plasma and Platelet-Related Products in the Treatment of Radiculopathy-A Systematic Review of the Literature. [europepmc]
• Correlation of multifidus degeneration with sex, age and side of herniation in patients with lumbar disc herniation. [europepmc]
• Causal association between circulating inflammatory markers and sciatica development: a Mendelian randomization study. [europepmc]