2013/07/25 by Eva A. A. Pogna, Pogna, E. A. A., Cristian Rodríguez-Tinoco +7
Chemistry · Materials Science · Pharmacology, Toxicology and Pharmaceutics · #Crystallography and molecular interactions #Disordered Systems and Neural Networks (cond-mat.dis-nn) #Drug Solubulity and Delivery Systems #FOS: Physical sciences #Material Dynamics and Properties
paper · pdf · doi:10.48550/arxiv.1307.6767
openalex publication_date 2013/07/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
The high frequency dynamics of Indomethacin and Celecoxib glasses has been investigated by inelastic x-ray scattering, accessing a momentum-energy region still unexplored in amorphous pharmaceuticals. We find evidence of phonon-like acoustic dynamics, and determine the THz behavior of sound velocity and acoustic attenuation. Connections with ordinary sound propagation are discussed, along with the relation between fast and slow degrees of freedom as represented by non-ergodicity factor and kinetic fragility, respectively.