2016/10/24 by Arnim Hellweg, Hellweg, Arnim, Frank Eckert +1
Physics and Astronomy · #Advanced Chemical Physics Studies #Advanced Thermodynamics and Statistical Mechanics #Chemical Physics (physics.chem-ph) #FOS: Physical sciences #Spectroscopy and Quantum Chemical Studies #physics.chem-ph
paper · pdf · doi:10.48550/arxiv.1610.07370
openalex publication_date 2016/10/24 · arxiv created 2017/02/13 · arxiv updated 2017/02/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
The computational modelling of reactions is simple in theory but can be quite tricky in practice. This article aims at the purpose of providing an assistance to a proper way of describing reactions theoretically and provides rough guidelines to the computational methods involved. Reactions in liquid phase chemical equilibrium can be described theoretically in terms of the Gibbs free energy of reaction. This property can be divided into a sum of three disjunct terms, namely the gas phase reaction energy, the finite temperature contribution to the Gibbs free energy, and the Gibbs free energy of solvation. The three contributions to the Gibbs free energy of reaction can be computed separately, using different theoretico--chemical calculation methods. While some of these terms can be obtained reliably by computationally cheap methods, for others a high level of theory is required to obtain predictions of quantitative quality. In order to propose workflows which can strike the balance between accuracy and computational cost, a number of benchmarks assessing the precision of different levels of theory is given. As an illustrative example, the low-temperature hydrogenation reaction of acetaldehyde to ethanol in solvent toluene is shown.