The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat

1971/11/01 by J. O'Keefe, John O’Keefe, J. Dostrovsky +1 · 163 citations
Neuroscience · #Memory and Neural Mechanisms #Sleep and Wakefulness Research #Neural dynamics and brain function

paper · doi:10.1016/0006-8993(71)90358-1

Cited by

• Comparative Contemplations on the Hippocampus
• Dynamical principles in neuroscience
• Navigating uncertainty: reward location variability induces reorganization of hippocampal spatial representations
• Graded encoding of spatial novelty scales in the human brain
• Spatial learning and lateralization in lizards
• From movement to cognitive maps: recurrent neural networks reveal how locomotor development shapes hippocampal spatial coding
• Cognitive Maps in the Prefrontal Cortex
• Efficient coding in working memory is adapted to the structure of the environment
• Sparse-to-dense coding transformation between hippocampal areas CA3 and CA1
• It’s All In The Journey: Putative Strategies Extracted from Navigation Paths Predict Spatial Memory and Hippocampal Recruitment
• Universal Principles of Navigation across Species and Spatial Scales
• Fragmented replay of very large environments in the hippocampus of bats
• Hippocampal-entorhinal cognitive maps and cortical motor system represent action plans and their outcomes
• Hippocampal coding of identity, sex, hierarchy, and affiliation in a social group of wild fruit bats
• Deconstruction of a memory engram reveals distinct ensembles recruited at learning
• What is episodic memory if it is a natural kind?
• Trial-unique, delayed nonmatching-to-location (TUNL) touchscreen testing for mice: sensitivity to dorsal hippocampal dysfunction
• Hippocampal GABAergic Inhibitory Interneurons
• Brain-Machine Interfaces: From Basic Science to Neuroprostheses and Neurorehabilitation
• Learning, Reward, and Decision Making
• X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women
• Hippocampal neurons construct a map of an abstract value space
• A simple model of co-emergence of grid and place fields
• Spatial navigation in preclinical Alzheimer's disease: A review
• Neural geometry in the human hippocampus enables generalization across spatial position and gaze
• Cross-View World Models
• Schema-based active inference supports rapid generalization of experience and frontal cortical coding of abstract structure
• Semantic Tuning of Single Neurons in the Human Medial Temporal Lobe
• Head-direction cells as a neural compass in bats navigating outdoors on a remote oceanic island
• Neuronal activity underlying vocal production in bats
• Disordered Hippocampal Reactivations Predict Spatial Memory Deficits in a Mouse Model of Alzheimer’s Disease
• The hippocampus: A manifesto for change.
• Differential effects of bilateral hippocampal CA3 damage on the implicit learning and recognition of complex event sequences
• Spatial coding supports auditory conceptual navigation
• FARM: Find Anything using Relational Spatial Memory
• Beyond Sliding Windows: Learning to Manage Memory in Non-Markovian Environments
• The visual challenges of short-range navigation in teleost fish
• A Spiking Neural Network Implementation of Gaussian Belief Propagation
• Neuronal hyperactivity – A key defect in Alzheimer's disease?
• Learning place cells and remapping by decoding the cognitive map
• Covering Relations in the Poset of Combinatorial Neural Codes
• A framework for disentangling spatial and visual neural representations
• NeuroPath: Neurobiology-Inspired Path Tracking and Reflection for Semantically Coherent Retrieval
• Entorhinal cortex dysfunction in Alzheimer's disease
• Large Associative Memory Problem in Neurobiology and Machine Learning
• Spatial Reasoning in Multimodal Large Language Models: A Survey of Tasks, Benchmarks and Methods
• A vascular code for speed in the spatial navigation system
• Selectivity considered harmful: evaluating the causal impact of class selectivity in DNNs
• Sublayer-Specific Coding Dynamics during Spatial Navigation and Learning in Hippocampal Area CA1
• Active experience, not time, determines within-day representational drift in dorsal CA1
• Generative Predictive Codes by Multiplexed Hippocampal Neuronal Tuplets
• On the supra-linear storage in dense networks of grid and place cells
• CA3 transiently modulates spatial representation in CA1
• Cognitive tasks could be biased towards generalists: a lesson from wild non-eusocial bees
• Contribution of multiple sensory information to place field stability in hippocampal place cells
• Abnormal c-Fos expression in TetTag mice containing fos-EGFP
• Transformations of the spatial activity manifold convey aversive information in CA3
• What is the mammalian dentate gyrus good for?
• Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice
• The neuroscience of remote spatial memory: A tale of two cities
• Phase relationship between hippocampal place units and the EEG theta rhythm
• Path integration in mammals
• Experience‐dependent modifications of hippocampal place cell firing
• From grid cells to place cells: A mathematical model
• Hippocampal spatial view cells for memory and navigation, and their underlying connectivity in humans
• Extrahippocampal contributions to spatial navigation in humans: A review of the neuroimaging evidence
• Complementary representations of time in the prefrontal cortex and hippocampus
• A three‐plane architectonic atlas of the rat hippocampal region
• Contributions of human hippocampal subfields to spatial and temporal pattern separation
• Significance of visual scene‐based learning in the hippocampal systems across mammalian species
• The influence of objects on place field expression and size in distal hippocampal CA1
• Cognitive mapping style relates to posterior–anterior hippocampal volume ratio
• Tactile modulation of hippocampal place fields
• Parahippocampal and retrosplenial connections of rat posterior parietal cortex
• Neurobiological successor features for spatial navigation
• Neural network modeling of the hippocampal formation spatial signals and their possible role in navigation: A modular approach
• Role of self‐generated odor cues in contextual representation
• Memory engrams: Recalling the past and imagining the future
• Living off the grid: Spatial representations show systematic non-Euclidean distortions regardless of their age and how measured
• Lost in time: Relocating the perception of duration outside the brain
• Hippocampus supports multi-task reinforcement learning under partial observability
• MULTIMODAL SENSORY INTEGRATION AND CONCURRENT NAVIGATION STRATEGIES FOR SPATIAL COGNITION IN REAL AND ARTIFICIAL ORGANISMS
• A Model of Place Field Reorganization During Reward Maximization
• Local feedback inhibition tightly controls rapid formation of hippocampal place fields
• Toward a functional future for the cognitive neuroscience of human aging
• An optical brain-machine interface reveals a causal role of posterior parietal cortex in goal-directed navigation
• Active inference on discrete state-spaces: A synthesis
• Modelling hydrodynamic processes within Pumicestone Passage, Northern Moreton Bay, Queensland
• Spatial representability of neuronal activity
• Spatial Olfactory Learning Contributes to Place Field Formation in the Hippocampus
• Theta phase precession in hippocampal neuronal populations and the compression of temporal sequences
• Study of CA1 place cell activity and exploratory behavior following spatial and nonspatial changes in the environment
• Topological coding in hippocampus
• Effects of Novelty and Temporal Distance on Postexperience Spike Patterns of Hippocampal Place Cells Encoding Multiple Environments
• Improved Accuracy of Robot Localization Using 3-D LiDAR in a Hippocampus-Inspired Model
• Place field dynamics in retrosplenial cortex compared to hippocampus
• Diverse calcium dynamics underlie place field formation in hippocampal CA1 pyramidal cells
• Temporally Structured Replay of Awake Hippocampal Ensemble Activity during Rapid Eye Movement Sleep
• Measuring information spatial densities
• Category learning in deep neural networks: Information content and geometry of internal representations
• Maintenance of multiple working memory items by temporal segmentation
• Semantic representations emerge in biologically inspired ensembles of cross-supervising neural networks
• Précis of<i>The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system</i>
• Emergence of Spatial Representation in an Actor-Critic Agent with Hippocampus-Inspired Sequence Generator
• Distinct hippocampal codes emerge during brain-machine interface navigation
• Deep Learning-based Stress Determinator for Mouse Psychiatric Analysis using Hippocampus Activity
• Copia de la Contestación a la consulta anterior, a la que acompañaron dos ejemplares del Arancel de la Junta
• Spatial and behavioral correlates of hippocampal neuronal activity
• Heterogeneous Modulation of Place Cell Firing by Changes in Context
• Goal-Related Activity in Hippocampal Place Cells
• Superficially Projecting Principal Neurons in Layer V of Medial Entorhinal Cortex in the Rat Receive Excitatory Retrosplenial Input
• Deconstruction of a memory engram reveals distinct ensembles recruited at learning
• No spatial advantage in adolescent hockey players? Exploring measure specificity and masked effects
• Age-related deficits in reference frame switching of navigation ability
• パイパ-工法の特長と実施例 (シリ-ズ:最近の小口径管推進工法とその施工事例-5-)
• A map of abstract relational knowledge in the human hippocampal–entorhinal cortex
• Advances in cellular resolution microscopy for brain imaging in rats
• Navigation-related structural change in the hippocampi of taxi drivers
• Real-Time Readout of Large-Scale Unsorted Neural Ensemble Place Codes
• How Reward and the Elimination of Dependence Thereon Lead Evolution to High-Bandwidth Learning
• When and Where: A Model Hippocampal Network Unifies Formation of Time Cells and Place Cells
• Uncertainty underlies geometric effects on navigation and grid-cell tuning
• Predictive coding of reward in the hippocampus
• Spatial dissociation between recognition and navigation in the primate hippocampus
• Navigating image space
• The Discovery of Head Direction Cells: A Personal Account
• Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory
• How heterogeneous place cell responding arises from homogeneous grids—A contextual gating hypothesis
• Predictive learning as a network mechanism for extracting low-dimensional latent space representations
• The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations
• Dopamine D₁Receptor Modulates Hippocampal Representation Plasticity to Spatial Novelty
• Why do humans reason? Arguments for an argumentative theory
• Replays of spatial memories suppress topological fluctuations in cognitive map
• Compact internal representation of dynamic situations: neural network implementing the causality principle
• Decoding Neuronal Ensembles from Spatially-Referenced Calcium Traces: A Bayesian Semiparametric Approach
• Strengthening Relationships between Neural Ideals and Receptive Fields
• Improved spatial memory in a modular network mimicking the prefrontal-thalamo-hippocampal triangular circuit
• Synthetic POMDPs to Challenge Memory-Augmented RL: Memory Demand Structure Modeling
• What Does it Mean for a Neural Network to Learn a "World Model"?
• Reactivation of hippocampal cell assemblies: effects of behavioral state, experience, and EEG dynamics. [europepmc]
• Forward and reverse hippocampal place-cell sequences during ripples. [europepmc]
• Genetic dissection of neural circuits. [europepmc]
• Internally generated cell assembly sequences in the rat hippocampus. [europepmc]
• Hippocampal replay of extended experience. [europepmc]
• Intracellular dynamics of hippocampal place cells during virtual navigation. [europepmc]
• Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop. [europepmc]
• Are the dorsal and ventral hippocampus functionally distinct structures? [europepmc]
• Hippocampal replay is not a simple function of experience. [europepmc]
• Regulation of learning and memory by meningeal immunity: a key role for IL-4. [europepmc]
• The reorganization and reactivation of hippocampal maps predict spatial memory performance. [europepmc]
• Neurophysiological and computational principles of cortical rhythms in cognition. [europepmc]
• Functional imaging of hippocampal place cells at cellular resolution during virtual navigation. [europepmc]
• Hippocampal "time cells" bridge the gap in memory for discontiguous events. [europepmc]
• Control of sleep and wakefulness. [europepmc]
• The θ-γ neural code. [europepmc]
• Rhythms of the hippocampal network. [europepmc]
• In Situ Transcription Profiling of Single Cells Reveals Spatial Organization of Cells in the Mouse Hippocampus. [europepmc]
• Mapping of a non-spatial dimension by the hippocampal-entorhinal circuit. [europepmc]
• Hippocampal GABAergic Inhibitory Interneurons. [europepmc]
• The cognitive map in humans: spatial navigation and beyond. [europepmc]
• Predictive Processing: A Canonical Cortical Computation. [europepmc]
• Memory engrams: Recalling the past and imagining the future. [europepmc]
• Path integration and cognitive mapping in a continuous attractor neural network model. [europepmc]
• Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving Rat. [europepmc]