Hippocampal hypocellularity in the Ts65Dn mouse originates early in development

2006/07/08 by Hernan A. Lorenzi, Hernán Lorenzi, Roger H. Reeves · 25 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Down syndrome and intellectual disability research #Genetics and Neurodevelopmental Disorders #Alzheimer's disease research and treatments

paper · doi:10.1016/j.brainres.2006.05.022

Citations

• MRI Volumes of the Hippocampus and Amygdala in Adults With Down’s Syndrome With and Without Dementia

Cited by

• Differential effects of trisomy on brain shape and volume in related aneuploid mouse models. [europepmc]
• Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome. [europepmc]
• Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. [europepmc]
• Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome. [europepmc]
• Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for Down syndrome. [europepmc]
• Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn. [europepmc]
• A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog. [europepmc]
• Down syndrome--recent progress and future prospects. [europepmc]
• Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome. [europepmc]
• Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome. [europepmc]
• Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome. [europepmc]
• Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome. [europepmc]
• Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with down syndrome. [europepmc]
• The use of mouse models to understand and improve cognitive deficits in Down syndrome. [europepmc]
• A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome. [europepmc]
• Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome. [europepmc]
• Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model. [europepmc]
• Usp16 contributes to somatic stem-cell defects in Down's syndrome. [europepmc]
• Visuo-spatial ability in individuals with Down syndrome: is it really a strength? [europepmc]
• Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD). [europepmc]
• Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice. [europepmc]
• The GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome. [europepmc]
• Epigallocatechin-3-gallate (EGCG) consumption in the Ts65Dn model of Down syndrome fails to improve behavioral deficits and is detrimental to skeletal phenotypes. [europepmc]
• Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome. [europepmc]
• Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome. [europepmc]