Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice

2008/02/13 by Catharine H. Duman, Lee Schlesinger, David S. Russell +2 · 28 citations
Neuroscience · Medicine · #Nerve injury and regeneration #Adipose Tissue and Metabolism #Neurogenesis and neuroplasticity mechanisms

paper · doi:10.1016/j.brainres.2007.12.047

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• Mechanistic intersections between migraine and major depressive disorder
• Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise. [europepmc]
• Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse. [europepmc]
• Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation. [europepmc]
• The use of a running wheel to measure activity in rodents: relationship to energy balance, general activity, and reward. [europepmc]
• Exercise offers anxiolytic potential: a role for stress and brain noradrenergic-galaninergic mechanisms. [europepmc]
• Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan. [europepmc]
• Glucocorticoids orchestrate divergent effects on mood through adult neurogenesis. [europepmc]
• Physical exercise prevents stress-induced activation of granule neurons and enhances local inhibitory mechanisms in the dentate gyrus. [europepmc]
• Exercise as a novel treatment for drug addiction: a neurobiological and stage-dependent hypothesis. [europepmc]
• BDNF mediates adaptive brain and body responses to energetic challenges. [europepmc]
• Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment. [europepmc]
• Mice with altered BDNF signaling as models for mood disorders and antidepressant effects. [europepmc]
• Role of the dorsal medial habenula in the regulation of voluntary activity, motor function, hedonic state, and primary reinforcement. [europepmc]
• Exercise, energy intake, glucose homeostasis, and the brain. [europepmc]
• Inoculation stress hypothesis of environmental enrichment. [europepmc]
• Lifelong brain health is a lifelong challenge: from evolutionary principles to empirical evidence. [europepmc]
• 3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons. [europepmc]
• Exercise increases mTOR signaling in brain regions involved in cognition and emotional behavior. [europepmc]
• Molecular Mechanisms Underlying Cardiac Adaptation to Exercise. [europepmc]
• Physical Exercise for Treatment of Mood Disorders: A Critical Review. [europepmc]
• A Mechanism-Based Approach to Physical Therapist Management of Pain. [europepmc]
• The Effects of Acute Exercise on Mood, Cognition, Neurophysiology, and Neurochemical Pathways: A Review. [europepmc]
• Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases. [europepmc]
• Lactate Mediates the Effects of Exercise on Learning and Memory through SIRT1-Dependent Activation of Hippocampal Brain-Derived Neurotrophic Factor (BDNF). [europepmc]
• Voluntary Exercise Boosts Striatal Dopamine Release: Evidence for the Necessary and Sufficient Role of BDNF. [europepmc]