Exosome secretion is a key pathway for clearance of pathological TDP-43

2016/09/27 by Yohei Iguchi, Lara Eid, Martin Parent +9 · 32 citations
Medicine · #Amyotrophic Lateral Sclerosis Research #Neurogenetic and Muscular Disorders Research

paper · pdf · doi:10.1093/brain/aww237

Abstract

mutant. Thus, even though results suggest that exosomes containing pathological TDP-43 may play a key role in the propagation of TDP-43 proteinopathy, a therapeutic strategy for amyotrophic lateral sclerosis based on inhibition of exosome production would seem inappropriate, as in vivo data suggest that exosome secretion plays an overall beneficial role in neuronal clearance of pathological TDP-43.

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