Exosome secretion is a key pathway for clearance of pathological TDP-43

2016/09/27 by Yohei Iguchi, Lara Eid, Martin Parent +9 · 369 citations
Medicine · Neuroscience · #Amyotrophic Lateral Sclerosis Research #Amyotrophic lateral sclerosis #Apoptosis #Autophagy #Biochemistry #Biology #Cell biology #Disease #Exosome #Gene #Gene silencing #Medicine #Microvesicles #Neurogenetic and Muscular Disorders Research #Neuroscience #Pathology #Secretion #microRNA

paper · pdf · doi:10.1093/brain/aww237

published in Brain 139(12), 3187-3201 (Oxford University Press)

openalex publication_date 2016/09/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

mutant. Thus, even though results suggest that exosomes containing pathological TDP-43 may play a key role in the propagation of TDP-43 proteinopathy, a therapeutic strategy for amyotrophic lateral sclerosis based on inhibition of exosome production would seem inappropriate, as in vivo data suggest that exosome secretion plays an overall beneficial role in neuronal clearance of pathological TDP-43.

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