2024/01/01 by Masclef, Jean-Baptiste, Acs, Emmanuelle M. N., Koehnke, Jesko +2
Biochemistry, Genetics and Molecular Biology · Materials Science · #540 #Cytotoxicity #Drug-Delivery #Hydrogels: synthesis, properties, applications #Nanoparticle-Based Drug Delivery #Nanoprecipitation #Poly(ethylene Glycol) #Polysaccharides #biodegradable polymer synthesis and properties
paper · doi:10.15488/20020
openalex publication_date 2024/01/01 · openalex created_date 2025/11/12 · openalex updated_date 2026/07/01
Hydrophilic polymers have found ubiquitous use in drug delivery and novel polymer materials to advance drug delivery systems are highly sought after. Herein, an amylose mimic (PEGose) was combined with poly(lactic acid) (PLA) in an amphiphilic block copolymer to form PEG-free nanoparticles as an alternative to PEG-based nanomedicines. The block copolymer self-assembled into 150–200 nm particles with a narrow dispersity in aqueous environment. The formed nanoparticles were capable of encapsulation, the sustained release of both hydrophilic and hydrophobic dyes. Moreover, the nanoparticles were found to be remarkably stable and had a very low cytotoxicity and a high propensity to penetrate cells. These results highlight the potential of PEGose-b-PLA to be used in drug delivery with a new hydrophilic building block.