Prediction of diffusion coefficients of proteins

1990/02/20 by Myo T. Tyn, Todd W. Gusek · 27 citations
Chemistry · Chemical Engineering · Biochemistry, Genetics and Molecular Biology · #Diffusion Coefficients in Liquids #Chemical and Physical Properties in Aqueous Solutions #Protein purification and stability

paper · doi:10.1002/bit.260350402

Abstract

A correlation for predicting the diffusion coefficients of proteins at standard conditions is proposed by adapting the Stokes-Einstein equation to a model for the equivalent hydrodynamic sphere. The radius of gyration, which accounts for the size and shape of protein molecules in solution, was used in deriving the new correlation. The correlation successfully predicted the diffusion coefficients of proteins, for which experimental data were available, with a higher degree of accuracy than achieved by previous correlation methods.

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