Prediction of diffusion coefficients of proteins

1990/02/20 by Myo T. Tyn, Todd W. Gusek · 427 citations
Biochemistry, Genetics and Molecular Biology · Chemical Engineering · Chemistry · Mathematics · #Biological system #Biology #Chemical and Physical Properties in Aqueous Solutions #Chemistry #Computer science #Correlation #Correlation coefficient #Diffusion #Diffusion Coefficients in Liquids #Geometry #Hydrodynamic radius #Mathematics #Physical chemistry #Physics #Polymer #Protein purification and stability #RADIUS #Radius of gyration #Statistical physics #Statistics #Stokes radius #Thermodynamics

paper · doi:10.1002/bit.260350402

published in Biotechnology and Bioengineering 35(4), 327-338 (Wiley)

openalex publication_date 1990/02/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25

Abstract

A correlation for predicting the diffusion coefficients of proteins at standard conditions is proposed by adapting the Stokes-Einstein equation to a model for the equivalent hydrodynamic sphere. The radius of gyration, which accounts for the size and shape of protein molecules in solution, was used in deriving the new correlation. The correlation successfully predicted the diffusion coefficients of proteins, for which experimental data were available, with a higher degree of accuracy than achieved by previous correlation methods.

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