Protein‐ and peptide‐modified synthetic polymeric biomaterials

2010/01/01 by Ohm D. Krishna, Kristi L. Kiick · 26 citations
Chemistry · Materials Science · #Biochemistry #Biophysics #Chemistry #Combinatorial chemistry #Enzyme #Materials science #Nanotechnology #Organic chemistry #Peptide #Polymer #Polymer chemistry #Protein engineering #Self-healing hydrogels #Silk-based biomaterials and applications #Supramolecular Self-Assembly in Materials #Titin #biodegradable polymer synthesis and properties

paper · doi:10.1002/bip.21333

openalex publication_date 2010/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Abstract This review presents an overview on bio‐hybrid approaches of integrating the structural and functional features of proteins and peptides with synthetic polymers and the resulting unique properties in such hybrids, with a focus on bioresponsive/bioactive systems with biomaterials applications. The review is divided in two broad sections. First, we describe several examples of bio‐hybrids produced by combining versatile synthetic polymers with proteins/enzymes and drugs that have resulted in (1) hybrid materials based on responsive polymers, (2) responsive hydrogels based on enzyme‐catalyzed reactions, protein–protein interactions and protein–drug sensing, and (3) dynamic hydrogels based on conformational changes of a protein. Next, we present hybrids produced by combining synthetic polymers with peptides, classified based on the properties of the peptide domain: (1) peptides with different conformations, such as α‐helical, coiled‐coil, and β‐sheet; (2) peptides derived from structural protein domains such as silk, elastin, titin, and collagen; and (3) peptides with other biofunctional properties such as cell‐binding domains and enzyme‐recognized degradation domains. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94:32–48, 2010. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at [email protected]

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• Photoreactive elastin-like proteins for use as versatile bioactive materials and surface coatings. [europepmc]
• Collagen-like peptides and peptide-polymer conjugates in the design of assembled materials. [europepmc]
• A dendritic thioester hydrogel based on thiol-thioester exchange as a dissolvable sealant system for wound closure. [europepmc]
• Nanoparticles from renewable polymers. [europepmc]
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• Π-Clamp-mediated cysteine conjugation. [europepmc]
• Programmable hydrogels. [europepmc]
• Achieving Controlled Biomolecule-Biomaterial Conjugation. [europepmc]
• New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers. [europepmc]
• Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications-A Review. [europepmc]
• Tunable Polymeric Scaffolds for Enzyme Immobilization. [europepmc]
• Dynamically tunable light responsive silk-elastin-like proteins. [europepmc]
• Evaluating polymeric biomaterials to improve next generation wound dressing design. [europepmc]
• In vitro strategies for mimicking dynamic cell-ECM reciprocity in 3D culture models. [europepmc]
• Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering. [europepmc]

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