2025/08/01 by Sahoo, Mamalisa, Mahalik, Gyanranjan, Mishra, Monali +1
#Aspergillus #Immunocompromised patients #Non- dermatophyte mould #Onychomycosis
paper · doi:10.71637/tnhj.v25i2.907
Background: Onychomycosis is a chronic infection of the nail. The most common causative agent of onychomycosis due to non dermatophytic mould is Aspergillus. Objectives: This review aims to address the various complications of onychomycosis due to non- dermatophyte mould and to provide an update on the diagnosis and treatment of onychomycosis. Methods: Databases including PubMed, Google Scholar were searched to identify the relevant articles. The search strategies included case studies, research articles, and review papers published within the past 20 years. Results: We reviewed all available literature concerning onychomycosis. A literature search revealed 130 studies, for this review paper we included 33 articles evaluating the onychomycosis due to non-dermatophyte mould. Five were case reports, five were research studies, two were cross- sectional studies, one was a randomized controlled trial, and the remaining were review and systematic reviews. In this, 3.03% of included publications have an impact factor more than 15, 6.06% have an impact factor more than 8, 81.81% have an impact factor ranging between 1-5, and 9.09% have an impact factor less than 1. From all the searched data it showed that toenails are more prone to infections than the fingernails. Conclusion: Oral therapies are effective, but one disadvantage is that they have more side effects. Topical treatment is less effective and requires extended treatment because of the slow penetration to the nail plate but it has minimal adverse effects. Now, there are various new techniques that are quite promising like laser, photodynamic, plasma therapy, and oil from ethnomedicinal plants.