Lipid-Controlled Peptide Topology and Interactions in Bilayers: Structural Insights into the Synergistic Enhancement of the Antimicrobial Activities of PGLa and Magainin 2

2011/03/01 by Evgeniy S. Salnikov, Evgeniy S. Salnikov, Burkhard Bechinger · 22 citations
Immunology and Microbiology · Chemistry · Biochemistry, Genetics and Molecular Biology · #Antimicrobial Peptides and Activities #Polydiacetylene-based materials and applications #Lipid Membrane Structure and Behavior

paper · pdf · doi:10.1016/j.bpj.2011.01.070

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• Lipid-Mediated Interactions between the Antimicrobial Peptides Magainin 2 and PGLa in Bilayers
• Magainin 2 and PGLa in Bacterial Membrane Mimics I: Peptide-Peptide and Lipid-Peptide Interactions
• Membrane Interactions of Phylloseptin-1, -2, and -3 Peptides by Oriented Solid-State NMR Spectroscopy
• Charge-dependent insertion of the antimicrobial peptide magainin 2 into lipid monolayers probed by neutron reflectivity
• Response of GWALP transmembrane peptides to changes in the tryptophan anchor positions. [europepmc]
• The Curvature Induction of Surface-Bound Antimicrobial Peptides Piscidin 1 and Piscidin 3 Varies with Lipid Chain Length. [europepmc]
• Pore Structure and Synergy in Antimicrobial Peptides of the Magainin Family. [europepmc]
• Molecular mechanism of synergy between the antimicrobial peptides PGLa and magainin 2. [europepmc]
• Biophysical Investigations Elucidating the Mechanisms of Action of Antimicrobial Peptides and Their Synergism. [europepmc]
• Structure, Topology, and Dynamics of Membrane-Inserted Polypeptides and Lipids by Solid-State NMR Spectroscopy: Investigations of the Transmembrane Domains of the DQ Beta-1 Subunit of the MHC II Receptor and of the COP I Protein p24. [europepmc]
• Magainin 2 and PGLa in Bacterial Membrane Mimics I: Peptide-Peptide and Lipid-Peptide Interactions. [europepmc]
• Effect of helical kink in antimicrobial peptides on membrane pore formation. [europepmc]
• Chiral supramolecular architecture of stable transmembrane pores formed by an α-helical antibiotic peptide in the presence of lyso-lipids. [europepmc]
• Highly synergistic antimicrobial activity of magainin 2 and PGLa peptides is rooted in the formation of supramolecular complexes with lipids. [europepmc]
• Study of the Interaction of a Novel Semi-Synthetic Peptide with Model Lipid Membranes. [europepmc]
• The Reversible Non-covalent Aggregation Into Fibers of PGLa and Magainin 2 Preserves Their Antimicrobial Activity and Synergism. [europepmc]
• Cooperative Function of LL-37 and HNP1 Protects Mammalian Cell Membranes from Lysis. [europepmc]
• Protection or Destruction: The LL-37/HNP1 Cooperativity Switch. [europepmc]
• Revealing the Mechanisms of Synergistic Action of Two Magainin Antimicrobial Peptides. [europepmc]
• Probing and Manipulating the Lateral Pressure Profile in Lipid Bilayers Using Membrane-Active Peptides-A Solid-State 19 F NMR Study. [europepmc]
• Therapeutic Potential of Antimicrobial Peptide PN5 against Multidrug-Resistant E. coli and Anti-Inflammatory Activity in a Septic Mouse Model. [europepmc]
• Binding and dimerization of PGLa peptides in anionic lipid bilayer studied by replica exchange molecular dynamics. [europepmc]