2018/09/28 by Tingfeng Yao, Shuai Yu, Yao, Tingfeng +5
Engineering · Medicine · Physics and Astronomy · #Biological Physics (physics.bio-ph) #FOS: Physical sciences #Nanoplatforms for cancer theranostics #Optical Imaging and Spectroscopy Techniques #Optics (physics.optics) #Photoacoustic and Ultrasonic Imaging #physics.bio-ph #physics.optics
paper · pdf · doi:10.48550/arxiv.1810.04997
14 pages, 6 figures
arxiv created 2018/09/28 · openalex publication_date 2018/09/28 · arxiv updated 2018/10/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Ultrasound-switchable fluorescence (USF) imaging was recently developed to overcome the limitation of the poor spatial resolution of the conventional fluorescence imaging in centimeter-deep tissue. However, in vivo USF imaging has not been achieved so far because of the lack of stable near-infrared contrast agents in a biological environment and the lack of data about their biodistributions. In this study, for the first time, we achieved in vivo USF imaging successfully in mice with high resolution. USF imaging in porcine heart tissue and mouse breast tumor via local injections were studied and demonstrated. In vivo and ex vivo USF imaging of the mouse spleen via intravenous injections was also successfully achieved. The results showed that the USF contrast agent adopted in this study was very stable in a biological environment, and it was mainly accumulated into the spleen of the mice. All the results of USF imaging were validated by a commercial micro-CT.