2024/04/14 by Yanlin Zhou, Tong Zhan, Zhou, Yanlin +7
Biochemistry, Genetics and Molecular Biology · #Artificial Intelligence (cs.AI) #Biomolecules (q-bio.BM) #FOS: Biological sciences #FOS: Computer and information sciences #Machine Learning (cs.LG) #RNA Research and Splicing #RNA and protein synthesis mechanisms #RNA modifications and cancer
paper · pdf · doi:10.48550/arxiv.2405.06655
openalex publication_date 2024/04/14 · openalex created_date 2024/05/15 · openalex updated_date 2026/07/28
The Human Genome Project has led to an exponential increase in data related to the sequence, structure, and function of biomolecules. Bioinformatics is an interdisciplinary research field that primarily uses computational methods to analyze large amounts of biological macromolecule data. Its goal is to discover hidden biological patterns and related information. Furthermore, analysing additional relevant information can enhance the study of biological operating mechanisms. This paper discusses the fundamental concepts of RNA, RNA secondary structure, and its prediction.Subsequently, the application of machine learning technologies in predicting the structure of biological macromolecules is explored. This chapter describes the relevant knowledge of algorithms and computational complexity and presents a RNA tertiary structure prediction algorithm based on ResNet. To address the issue of the current scoring function's unsuitability for long RNA, a scoring model based on ResNet is proposed, and a structure prediction algorithm is designed. The chapter concludes by presenting some open and interesting challenges in the field of RNA tertiary structure prediction.