2024/07/13 by Gweba, Cornelius, Ojule, I. N., Panwal, M. T. +2
#MDR-TB and Diagnosis #Mycobacterium tuberculosis complex #Nigeria #species
paper · doi:10.60787/tnhj.v23i4.707
In Nigeria and other low-and-middle-income countries, majority of clinical laboratories use Gene Xpert MTB/RIF assay, Hain lifescience MTBDRplus and MTBDRsl for rapid diagnosis of both TB and MDR-TB. These tools diagnose TB disease caused by members of Mycobacterium tuberculosis complex (MTBC), but do not differentiate among members of the MTBC to the species level. Knowledge of the circulating strains of MTBC in a population is critical for effective TB control measures. In this study, 96 MDR-TB strains isolated from patients in Southeast Nigeria were differentiated to species level using Geno Type MTBC kit. Of the 96, 58.30% (n=56) were M. tuberculosis/M. canettii, 11.45% (n=11) were M. africanum and 2.10% (n=2) were M. bovis. However, 11.45% (n=11) were high gram-positive bacteria, 14.60% (n=14) were invalid, while 2.10% (n=2) had no evaluable pattern. Our findings shows that M. tuberculosis/M. canettii and M. africanum are the leading cause of MDR-TB in Southeast Nigeria. Our findings show that M tuberculosis/M. canettii and M. africanum are the leading causes of MDR-TB amongst the study population. Furthermore, the results of this study indicate that M. bovis remains an important cause of tuberculosis particularly amongst groups at risk.