2021/09/22 by Bozadjieva-Kramer, Nadejda, Shin, Jae Hoon, Shao, Yikai +9
#Adipose Tissue #Animal #Animals #Bariatric Surgery #Bile Acids and Salts #Blood Glucose #Bone Density #Bone Marrow #Diabetes Mellitus #Diet #Disease Models #Fibroblast Growth Factors #Gastrectomy #Glucose Tolerance Test #High-Fat #Homeostasis #Inbred C57BL #Knockout #Male #Mice #Obesity #Type 2 #Weight Loss
paper · doi:10.7302/2624
Bariatric surgeries such as the Vertical Sleeve Gastrectomy (VSG) are invasive but provide the most effective improvements in obesity and Type 2 diabetes. We hypothesized a potential role for the gut hormone Fibroblast-Growth Factor 15/19 which is increased after VSG and pharmacologically can improve energy homeostasis and glucose handling. We generated intestinal-specific FGF15 knockout (FGF15INT-KO) mice which were maintained on high-fat diet. FGF15INT-KO mice lost more weight after VSG as a result of increased lean tissue loss. FGF15INT-KO mice also lost more bone density and bone marrow adipose tissue after VSG. The effect of VSG to improve glucose tolerance was also absent in FGF15INT-KO. VSG resulted in increased plasma bile acid levels but were considerably higher in VSG-FGF15INT-KO mice. These data point to an important role after VSG for intestinal FGF15 to protect the organism from deleterious effects of VSG potentially by limiting the increase in circulating bile acids.