The Impact of Mmu17 Non-Hsa21 Orthologous Genes in the Ts65Dn Mouse Model of Down Syndrome: The Gold Standard Refuted

2023/03/14 by Fayçal Guedj, Faycal Guedj, Elise Kane +6 · 15 citations
Medicine · Social Sciences · Neuroscience · #Down syndrome and intellectual disability research #Disability Rights and Representation #Autism Spectrum Disorder Research

paper · doi:10.1016/j.biopsych.2023.02.012

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• The placental effects of trisomy for human chromosome 21 orthologs in four mouse models of Down syndrome
• Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome. [europepmc]
• Dissection of a Down syndrome-associated trisomy to separate the gene dosage-dependent and -independent effects of an extra chromosome. [europepmc]
• Embryonic statistical analyses reveal 2 growth phenotypes in mouse models of Down syndrome. [europepmc]
• Ultrasonic vocalization phenotypes in the Ts65Dn and Dp(16)1Yey mouse models of Down syndrome. [europepmc]
• Glutamatergic synaptic deficits in the prefrontal cortex of the Ts65Dn mouse model for Down syndrome. [europepmc]
• Neocortical neuronal production and maturation defects in the TcMAC21 mouse model of Down syndrome. [europepmc]
• Senescent hearts from male Ts65Dn mice exhibit preserved function but altered size and nicotinamide adenine dinucleotide pathway signaling. [europepmc]
• Prenatal treatment with preimplantation factor improves early postnatal neurogenesis and cognitive impairments in a mouse model of Down syndrome. [europepmc]
• In and out: Benchmarking in vitro, in vivo, ex vivo, and xenografting approaches for an integrative brain disease modeling pipeline. [europepmc]
• Exploring crystallized and fluid intelligence in down syndrome using graph theory. [europepmc]
• Infantile Spasms in Pediatric Down Syndrome: Potential Mechanisms Driving Therapeutic Considerations. [europepmc]
• Disrupted Neurogenesis from Basal Intermediate Precursor Cells Alters the Postnatal Neocortex in the TcMAC21 Mouse Model of Down Syndrome. [europepmc]
• The placental effects of trisomy for human chromosome 21 orthologs in four mouse models of Down syndrome. [europepmc]
• Genetic analysis of triplicated genes affecting sex-specific skeletal deficits in Down syndrome model mice. [europepmc]