2019/08/16 by Md Mahfuzur Rahman Siddiquee, Zongwei Zhou, Siddiquee, Md Mahfuzur Rahman +11 · 1 citation
Computer Science · #AI in cancer detection #Computer Vision and Pattern Recognition (cs.CV) #Digital Media Forensic Detection #FOS: Computer and information sciences #FOS: Electrical engineering #Generative Adversarial Networks and Image Synthesis #Image and Video Processing (eess.IV) #electronic engineering #information engineering
paper · pdf · doi:10.48550/arxiv.1908.06965
openalex publication_date 2019/08/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Generative adversarial networks (GANs) have ushered in a revolution in image-to-image translation. The development and proliferation of GANs raises an interesting question: can we train a GAN to remove an object, if present, from an image while otherwise preserving the image? Specifically, can a GAN "virtually heal" anyone by turning his medical image, with an unknown health status (diseased or healthy), into a healthy one, so that diseased regions could be revealed by subtracting those two images? Such a task requires a GAN to identify a minimal subset of target pixels for domain translation, an ability that we call fixed-point translation, which no GAN is equipped with yet. Therefore, we propose a new GAN, called Fixed-Point GAN, trained by (1) supervising same-domain translation through a conditional identity loss, and (2) regularizing cross-domain translation through revised adversarial, domain classification, and cycle consistency loss. Based on fixed-point translation, we further derive a novel framework for disease detection and localization using only image-level annotation. Qualitative and quantitative evaluations demonstrate that the proposed method outperforms the state of the art in multi-domain image-to-image translation and that it surpasses predominant weakly-supervised localization methods in both disease detection and localization. Implementation is available at https://github.com/jlianglab/Fixed-Point-GAN.