Amyloid Plaques Disrupt Resting State Default Mode Network Connectivity in Cognitively Normal Elderly

2009/10/15 by Yvette I. Sheline, Marcus E. Raichle, Abraham Z. Snyder +4 · 28 citations
Neuroscience · Medicine · Psychology · #Functional Brain Connectivity Studies #Dementia and Cognitive Impairment Research #Mental Health Research Topics

paper · doi:10.1016/j.biopsych.2009.08.024

Cited by

• Non-linear associations of amyloid-β with resting-state functional networks and their cognitive relevance in a large community-based cohort of cognitively normal older adults
• Unraveling Alzheimer’s disease: Investigating dynamic functional connectivity in the default mode network through DCC-GARCH modeling
• Aging-dependent loss of functional connectivity in a mouse model of Alzheimer’s disease and reversal by mGluR5 modulator
• Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization. [europepmc]
• Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden. [europepmc]
• Clinical applications of resting state functional connectivity. [europepmc]
• APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42. [europepmc]
• Default mode network connectivity in stable vs progressive mild cognitive impairment. [europepmc]
• Amyloid-β associated cortical thinning in clinically normal elderly. [europepmc]
• Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. [europepmc]
• Face-name associative memory performance is related to amyloid burden in normal elderly. [europepmc]
• Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia. [europepmc]
• Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition. [europepmc]
• Characterizing variation in the functional connectome: promise and pitfalls. [europepmc]
• The restless brain. [europepmc]
• Loss of intranetwork and internetwork resting state functional connections with Alzheimer's disease progression. [europepmc]
• Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology. [europepmc]
• Resting state functional connectivity in preclinical Alzheimer's disease. [europepmc]
• The parahippocampal gyrus links the default-mode cortical network with the medial temporal lobe memory system. [europepmc]
• Functional connectivity and graph theory in preclinical Alzheimer's disease. [europepmc]
• Functional brain connectivity using fMRI in aging and Alzheimer's disease. [europepmc]
• The evolution of preclinical Alzheimer's disease: implications for prevention trials. [europepmc]
• Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults. [europepmc]
• Impairments of neural circuit function in Alzheimer's disease. [europepmc]
• Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals. [europepmc]
• What Happens with the Circuit in Alzheimer's Disease in Mice and Humans? [europepmc]
• Medial temporal lobe connectivity and its associations with cognition in early Alzheimer's disease. [europepmc]
• The role of the medial prefrontal cortex in cognition, ageing and dementia. [europepmc]