A Line of Mice Selected for High Blood Ethanol Concentrations Shows Drinking in the Dark to Intoxication

2008/12/19 by John C. Crabbe, Pamela Metten, Justin S. Rhodes +4 · 28 citations
Neuroscience · Medicine · Biochemistry, Genetics and Molecular Biology · #Neurotransmitter Receptor Influence on Behavior #Alcohol Consumption and Health Effects #Nicotinic Acetylcholine Receptors Study

paper · doi:10.1016/j.biopsych.2008.11.002

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• Limited access ethanol drinking in the dark in adolescent and adult mice
• Ethanol Drinking Microstructure of a High Drinking in the Dark Selected Mouse Line
• Ethanol Increases Diffuse Amyloid Plaque Load and Impairs Memory in the 5xFAD Mouse Model of Alzheimer's Disease
• Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism. [europepmc]
• Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes. [europepmc]
• The complexity of alcohol drinking: studies in rodent genetic models. [europepmc]
• Derivation and characterization of replicate high- and low-alcohol preferring lines of mice and a high-drinking crossed HAP line. [europepmc]
• Alcohol preference drinking in a mouse line selectively bred for high drinking in the dark. [europepmc]
• Intermittent (every-other-day) drinking induces rapid escalation of ethanol intake and preference in adolescent and adult C57BL/6J mice. [europepmc]
• Molecular profiles of drinking alcohol to intoxication in C57BL/6J mice. [europepmc]
• Preclinical studies of alcohol binge drinking. [europepmc]
• Modeling binge-like ethanol drinking by peri-adolescent and adult P rats. [europepmc]
• The neurobiology of binge-like ethanol drinking: evidence from rodent models. [europepmc]
• Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. [europepmc]
• Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity. [europepmc]
• Escalation of intake under intermittent ethanol access in diverse mouse genotypes. [europepmc]
• Selection for drinking in the dark alters brain gene coexpression networks. [europepmc]
• Binge alcohol drinking by mice requires intact group 1 metabotropic glutamate receptor signaling within the central nucleus of the amygdala. [europepmc]
• "Drinking in the dark" (DID) procedures: a model of binge-like ethanol drinking in non-dependent mice. [europepmc]
• Circadian rhythms and addiction: mechanistic insights and future directions. [europepmc]
• "Drinking in the Dark" (DID): a simple mouse model of binge-like alcohol intake. [europepmc]
• Alcohol, stress hormones, and the prefrontal cortex: a proposed pathway to the dark side of addiction. [europepmc]
• Alcohol binge drinking during adolescence or dependence during adulthood reduces prefrontal myelin in male rats. [europepmc]
• Binge alcohol drinking elicits persistent negative affect in mice. [europepmc]
• Rat animal models for screening medications to treat alcohol use disorders. [europepmc]
• Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice. [europepmc]
• Sex Differences in the Neurobiology of Alcohol Use Disorder. [europepmc]
• Recent Perspectives on Sex Differences in Compulsion-Like and Binge Alcohol Drinking. [europepmc]