Biophysical Sequence Analysis of Functional Differences of Piezo1 and Piezo2

2022/12/27 by J. C. Phillips, Phillips, J. C.
Biochemistry, Genetics and Molecular Biology · Medicine · #Blood properties and coagulation #Cellular Mechanics and Interactions #Erythrocyte Function and Pathophysiology #FOS: Biological sciences #Other Quantitative Biology (q-bio.OT)

paper · pdf · doi:10.48550/arxiv.2212.14754

openalex publication_date 2022/12/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

Because of their large size and widespread mechanosensitive interactions the only recently discovered titled transmembrane proteins have attracted much attention. Here we present and discuss their hydropathic profiles using a new method of sequence analysis. We find large-scale similarities and differences not obtainable by conventional sequence or structural studies. These differences support the evolution-towards-criticality conjecture popular among physicists.

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