2024/07/28 by Nagur Shareef Shaik, Teja Krishna Cherukuri, Shaik, Nagur Shareef +5 · 1 citation
Biochemistry, Genetics and Molecular Biology · #Artificial Intelligence (cs.AI) #Cell Image Analysis Techniques #Computer Vision and Pattern Recognition (cs.CV) #FOS: Biological sciences #FOS: Computer and information sciences #Genetics, Bioinformatics, and Biomedical Research #Machine Learning (cs.LG) #Neurons and Cognition (q-bio.NC)
paper · pdf · doi:10.48550/arxiv.2407.19385
openalex publication_date 2024/07/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Schizophrenia (SZ) is a severe brain disorder marked by diverse cognitive impairments, abnormalities in brain structure, function, and genetic factors. Its complex symptoms and overlap with other psychiatric conditions challenge traditional diagnostic methods, necessitating advanced systems to improve precision. Existing research studies have mostly focused on imaging data, such as structural and functional MRI, for SZ diagnosis. There has been less focus on the integration of genomic features despite their potential in identifying heritable SZ traits. In this study, we introduce a Multi-modal Imaging Genomics Transformer (MIGTrans), that attentively integrates genomics with structural and functional imaging data to capture SZ-related neuroanatomical and connectome abnormalities. MIGTrans demonstrated improved SZ classification performance with an accuracy of 86.05% (+/- 0.02), offering clear interpretations and identifying significant genomic locations and brain morphological/connectivity patterns associated with SZ.