Methyl (Alkyl)-Coenzyme M Reductases: Nickel F-430-Containing Enzymes Involved in Anaerobic Methane Formation and in Anaerobic Oxidation of Methane or of Short Chain Alkanes

2019/04/05 by Rudolf K. Thauer · 40 citations
Environmental Science · Biochemistry, Genetics and Molecular Biology · #Methane Hydrates and Related Phenomena #Porphyrin Metabolism and Disorders #Microbial metabolism and enzyme function

paper · pdf · doi:10.1021/acs.biochem.9b00164

Abstract

' = -140 mV) gets too high. Methanogens therefore harbor an enzyme system for the reactivation of inactivated MCR in an ATP-dependent reduction reaction. Purification of active MCR in the Ni(I) oxidation state is very challenging and has been achieved in only a few laboratories. This perspective reviews the function, structure, and properties of MCR, what is known and not known about the catalytic mechanism, how the inactive enzyme is reactivated, and what remains to be discovered.

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