Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1

2010/08/25 by Kathrin Mandery, Krystyna Bujok, Ingrid Schmidt +6 · 25 citations
Medicine · Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Drug Transport and Resistance Mechanisms #Natural product bioactivities and synthesis #Pharmacological Effects of Natural Compounds

paper · doi:10.1016/j.bcp.2010.08.008

Citations

• Fruit juices inhibit organic anion transporting polypeptide–mediated drug uptake to decrease the oral availability of fexofenadine
• Intestinal Drug Transporter Expression and the Impact of Grapefruit Juice in Humans
• Naringin is a Major and Selective Clinical Inhibitor of Organic Anion-Transporting Polypeptide 1A2 (OATP1A2) in Grapefruit Juice

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• Organic anion-transporting polypeptides. [europepmc]
• Prioritizing pharmacokinetic drug interaction precipitants in natural products: application to OATP inhibitors in grapefruit juice. [europepmc]
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• Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine. [europepmc]
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• Kaempferol activates chloride secretion via the cAMP/PKA signaling pathway and expression of CFTR in T84 cells. [europepmc]
• Flavonoid Interactions with Renal Organic Anion Transporters OAT1 and OAT3: Structure-Activity Relationships and Clinical Implications. [europepmc]