Urolithin A alleviates myocardial ischemia/reperfusion injury via PI3K/Akt pathway

2017/03/23 by Lu Tang, Yingli Mo, Yunpeng Li +7 · 26 citations
Nursing · Medicine · #Pomegranate: compositions and health benefits #Phytochemicals and Antioxidant Activities #Antioxidant Activity and Oxidative Stress

paper · doi:10.1016/j.bbrc.2017.03.119

Cited by

• Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
• An increased autophagic flux contributes to the anti-inflammatory potential of urolithin A in macrophages. [europepmc]
• Vasculoprotective Effects of Pomegranate ( Punica granatum L.). [europepmc]
• The protective effects of total paeony glycoside on ischemia/reperfusion injury in H9C2 cells via inhibition of the PI3K/Akt signaling pathway. [europepmc]
• Urolithin A-activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo. [europepmc]
• The ellagitannin metabolite urolithin C is a glucose-dependent regulator of insulin secretion through activation of L-type calcium channels. [europepmc]
• Salvianolic acid B protects against myocardial ischaemia-reperfusion injury in rats via inhibiting high mobility group box 1 protein expression through the PI3K/Akt signalling pathway. [europepmc]
• Long non‑coding RNA GAS5 regulates myocardial ischemia‑reperfusion injury through the PI3K/AKT apoptosis pathway by sponging miR‑532‑5p. [europepmc]
• Neuroprotective effects of urolithin A on H 2 O 2 -induced oxidative stress-mediated apoptosis in SK-N-MC cells. [europepmc]
• Mitochondrial Quality Control and Cellular Proteostasis: Two Sides of the Same Coin. [europepmc]
• Ellagic Acid-Derived Urolithins as Modulators of Oxidative Stress. [europepmc]
• Insight into Polyphenol and Gut Microbiota Crosstalk: Are Their Metabolites the Key to Understand Protective Effects against Metabolic Disorders? [europepmc]
• Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential. [europepmc]
• Immunomodulatory Role of Urolithin A on Metabolic Diseases. [europepmc]
• Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications. [europepmc]
• Pomegranate ( Punica granatum ) Phenolics Ameliorate Hydrogen Peroxide-Induced Oxidative Stress and Cytotoxicity in Human Keratinocytes. [europepmc]
• Acacetin Protects Myocardial Cells against Hypoxia-Reoxygenation Injury through Activation of Autophagy. [europepmc]
• Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease. [europepmc]
• Urolithin A prevents streptozotocin-induced diabetic cardiomyopathy in rats by activating SIRT1. [europepmc]
• Ameliorative effect of urolithin A on d-gal-induced liver and kidney damage in aging mice via its antioxidative, anti-inflammatory and antiapoptotic properties. [europepmc]
• Interplay between PI3K/AKT pathway and heart disorders. [europepmc]
• Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. [europepmc]
• Lactococcus garvieae FUA009, a Novel Intestinal Bacterium Capable of Producing the Bioactive Metabolite Urolithin A from Ellagic Acid. [europepmc]
• The Therapeutic Relevance of Urolithins, Intestinal Metabolites of Ellagitannin-Rich Food: A Systematic Review of In Vivo Studies. [europepmc]
• Punicalagin Protects against the Development of Methotrexate-Induced Hepatotoxicity in Mice via Activating Nrf2 Signaling and Decreasing Oxidative Stress, Inflammation, and Cell Death. [europepmc]
• Urolithin A in Health and Diseases: Prospects for Parkinson's Disease Management. [europepmc]