SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia

2015/05/13 by Hyun-Yoo Joo, Miyong Yun, Jaemin Jeong +11 · 26 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Sirtuins and Resveratrol in Medicine #Endoplasmic Reticulum Stress and Disease #Cancer, Hypoxia, and Metabolism

paper · doi:10.1016/j.bbrc.2015.04.119

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• NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer. [europepmc]
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• Hypoxia-Induced Cancer Cell Responses Driving Radioresistance of Hypoxic Tumors: Approaches to Targeting and Radiosensitizing. [europepmc]
• SIRT1/PGC-1α/PPAR-γ Correlate With Hypoxia-Induced Chemoresistance in Non-Small Cell Lung Cancer. [europepmc]
• Icariin improves testicular dysfunction via enhancing proliferation and inhibiting mitochondria-dependent apoptosis pathway in high-fat diet and streptozotocin-induced diabetic rats. [europepmc]
• Potential of Polyphenols to Restore SIRT1 and NAD+ Metabolism in Renal Disease. [europepmc]
• Regulation of SIRT1 and Its Roles in Inflammation. [europepmc]
• Hypoxia in Aging and Aging-Related Diseases: Mechanism and Therapeutic Strategies. [europepmc]
• Emerging role of hypoxia-inducible factor-1α in inflammatory autoimmune diseases: A comprehensive review. [europepmc]
• New Dawn for Atherosclerosis: Vascular Endothelial Cell Senescence and Death. [europepmc]
• STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice. [europepmc]