Role of Smad4 (DPC4) inactivation in human cancer

2003/06/20 by Michiko Miyaki, Toshio Kuroki · 25 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Adenomatous polyposis coli #Allele #Biology #Cancer #Cancer research #Carcinogenesis #Colorectal cancer #Frameshift mutation #Gene #Genetic factors in colorectal cancer #Genetics #Missense mutation #Mutation #Nonsense mutation #Pancreatic and Hepatic Oncology Research #TGF-β signaling in diseases #Tumor suppressor gene

paper · doi:10.1016/s0006-291x(03)01066-0

openalex publication_date 2003/06/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/27

Cited by

• Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS. [europepmc]
• Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells. [europepmc]
• Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis. [europepmc]
• Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis. [europepmc]
• Fabrication of gold nanoparticles for targeted therapy in pancreatic cancer. [europepmc]
• Dual effects of TGF-beta on ERalpha-mediated estrogenic transcriptional activity in breast cancer. [europepmc]
• Genetic variation in the TGF-β signaling pathway and colon and rectal cancer risk. [europepmc]
• Smad4 inactivation promotes malignancy and drug resistance of colon cancer. [europepmc]
• Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice. [europepmc]
• Alterations in the Smad pathway in human cancers. [europepmc]
• Genomic sequencing of key genes in mouse pancreatic cancer cells. [europepmc]
• Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling. [europepmc]
• A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor β receptor signaling. [europepmc]
• ErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis. [europepmc]
• Advanced Proteogenomic Analysis Reveals Multiple Peptide Mutations and Complex Immunoglobulin Peptides in Colon Cancer. [europepmc]
• Colorectal cancer models for novel drug discovery. [europepmc]
• Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks. [europepmc]
• The role of epithelial to mesenchymal transition in resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. [europepmc]
• Morphologic and molecular study of lung cancers associated with idiopathic pulmonary fibrosis and other pulmonary fibroses. [europepmc]
• SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling. [europepmc]
• Roles of Smads Family and Alternative Splicing Variants of Smad4 in Different Cancers. [europepmc]
• Sunitinib-suppressed miR-452-5p facilitates renal cancer cell invasion and metastasis through modulating SMAD4/SMAD7 signals. [europepmc]
• Mutant FOXL2 C134W Hijacks SMAD4 and SMAD2/3 to Drive Adult Granulosa Cell Tumors. [europepmc]
• Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling. [europepmc]
• Significance of TP53, CDKN2A, SMAD4 and KRAS in Pancreatic Cancer. [europepmc]