2011/12/04 by Thomas V. Wiecki, Michael J. Frank, Wiecki, Thomas V. +1
Medicine · Neuroscience · #FOS: Biological sciences #Memory and Neural Mechanisms #Neural dynamics and brain function #Neurological disorders and treatments #Neurons and Cognition (q-bio.NC) #Neuroscience and Neuropharmacology Research
paper · pdf · doi:10.48550/arxiv.1112.0778
openalex publication_date 2011/12/04 · openalex created_date 2025/10/27 · openalex updated_date 2026/07/28
Planning and executing volitional actions in the face of conflicting habitual\nresponses is a critical aspect of human behavior. At the core of the interplay\nbetween these two control systems lies an override mechanism that can suppress\nthe habitual action selection process and allow executive control to take over.\nHere, we construct a neural circuit model informed by behavioral and\nelectrophysiological data collected on various response inhibition paradigms.\nThis model extends a well established model of action selection in the basal\nganglia by including a frontal executive control network which integrates\ninformation about sensory input and task rules to facilitate well-informed\ndecision making via the oculomotor system. Our simulations of the antisaccade,\nSimon and saccade-override task ensue in conflict between a prepotent and\ncontrolled response which causes the network to pause action selection via\nprojections to the subthalamic nucleus. Our model reproduces key behavioral and\nelectrophysiological patterns and their sensitivity to lesions and\npharmacological manipulations. Finally, we show how this network can be\nextended to include the inferior frontal cortex to simulate key qualitative\npatterns of global response inhibition demands as required in the stop-signal\ntask.\n