2009/06/13 by Liaofu Luo, Luo, Liaofu
Biochemistry, Genetics and Molecular Biology · Materials Science · #ATP Synthase and ATPases Research #Biomolecules (q-bio.BM) #Enzyme Structure and Function #FOS: Biological sciences #Protein Structure and Dynamics #Quantitative Methods (q-bio.QM) #q-bio.BM #q-bio.QM
paper · pdf · doi:10.48550/arxiv.0906.2452
18 pages
arxiv created 2009/06/13 · openalex publication_date 2009/06/13 · arxiv updated 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
The importance of torsion vibration in the transmission of life information is indicated. The localization of quantum torsion state is proved. Following these analyses a formalism on the quantum theory of conformation-electron system is proposed. The conformational-electronic transition is calculated by non-adiabatic operator method. The protein folding is viewed from conformational quantum transition and the folding rate is calculated. The time-scale of microsecond to millisecond for the fundamental folding event (nucleation, collapse, etc) is deduced. The dependence of transition rate W on N inertial moments is given. It indicates how W increases with the number N of torsion angles and decreases with the inertial moment I of atomic group in cooperative transition. The temperature dependence is also deduced which is different from chemical reaction in high-temperature region. It is demonstrated that the conformational dynamics gives deep insights into the folding mechanism and provides a useful tool for analyzing and explaining experimental facts on the rate of protein folding.