2023/09/21 by Vianney Brouard, Brouard, Vianney · 1 citation
Biochemistry, Genetics and Molecular Biology · #60F99 #60J27 #60J80 #92D15 #92D25 #Evolution and Genetic Dynamics #FOS: Biological sciences #FOS: Mathematics #Plant biochemistry and biosynthesis #Populations and Evolution (q-bio.PE) #Probability (math.PR)
paper · pdf · doi:10.48550/arxiv.2309.12055
openalex publication_date 2023/09/21 · openalex created_date 2023/09/23 · openalex updated_date 2026/07/28
We aim to understand the evolution of the genetic composition of cancer cell populations. To achieve this, we consider an individual-based model representing a cell population where cells divide, die and mutate along the edges of a finite directed graph (V,E). The process starts with only one cell of trait 0. Following typical parameter values in cancer cell populations we study the model under power law mutation rates, in the sense that the mutation probabilities are parametrized by negative powers of a scaling parameter n and the typical sizes of the population of interest are positive powers of n. Under a non-increasing growth rate condition, we describe the time evolution of the first-order asymptotics of the size of each subpopulation in the log(n) time scale, as well as in the random time scale at which the wild-type population, resp. the total population, reaches the size nt. In particular, such results allow for the perfect characterization of evolutionary pathways. Without imposing any conditions on the growth rates, we describe the time evolution of the order of magnitude of each subpopulation, whose asymptotic limits are positive non-decreasing piecewise linear continuous functions.