2015/05/14 by Jicun Wang-Michelitsch, Wang-Michelitsch, Jicun, Thomas M. Michelitsch +1
Biochemistry, Genetics and Molecular Biology · #DNA Repair Mechanisms #FOS: Biological sciences #Mitochondrial Function and Pathology #Nuclear Structure and Function #Tissues and Organs (q-bio.TO) #q-bio.TO
paper · pdf · doi:10.48550/arxiv.1505.03905
10 pages, 1 figure
openalex publication_date 2015/05/14 · arxiv created 2017/09/06 · arxiv updated 2017/09/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Hutchinson-Gilford Progeria syndrome, Werner syndrome, and Cockayne syndrome are three genetic disorders, in which the children have premature aging features. To understand the phenomenon of premature aging, the similarity of aging features in these syndromes to that in normal aging is investigated. Although these three syndromes have different genetic backgrounds, all the patients have abnormal structures of tissues/organs like that in normal aging. Therefore, the abnormality in tissue structure is the common point in premature aging and normal aging. This abnormality links also a defective development and a defective repair, the Misrepair. Defective development is a result of Mis-construction of the structure of tissues and organs as consequence of genetic mutations. Aging is a result of Mis-reconstructions, the Misrepairs, for maintaining the structure of tissues/organs. Construction-reconstruction of the structure of an organism is thus the coupling point of development and aging. Mis- construction and Mis-reconstruction (Misrepair) are the essential processes for the development of aging-like feathers. In conclusion, premature aging is a result of Mis- construction of tissues and organs during body development as consequence of genetic disorders.