2021/10/13 by R. A. Rytov, Rytov, R. A., V. A. Bautin +3
Earth and Planetary Sciences · Engineering · Physics and Astronomy · #Advanced Thermodynamics and Statistical Mechanics #Applied Physics (physics.app-ph) #Characterization and Applications of Magnetic Nanoparticles #FOS: Physical sciences #Mesoscale and Nanoscale Physics (cond-mat.mes-hall) #nanoparticles nucleation surface interactions
paper · pdf · doi:10.48550/arxiv.2110.06883
openalex publication_date 2021/10/13 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
A linear combination of spherically symmetric heat sources is shown to provide optimal stationary thermal distribution in magnetic hyperthermia. Furthermore, such spatial location of heat sources produces suitable temperature distribution in biological medium even for assemblies of magnetic nanoparticles with a moderate value of specific absorption rate (SAR), of the order of 100 - 150 W/g. We also demonstrate the advantage of using assemblies of magnetic nanocapsules consisting of metallic iron nanoparticles covered with non magnetic shells of sufficient thickness in magnetic hyperthermia. Based on numerical simulation we optimize the size and geometric structure of biocompatible capsules in order to minimize the influence of strong magneto-dipole interaction between closely spaced nanoparticles. It is shown that assembly of capsules can provide sufficiently high SAR values of the order of 250 - 400 W/g at moderate amplitudes H = 50 - 100 Oe and frequencies f = 100 - 200 kHz of alternating magnetic field, being appropriate for application in clinics