2013/01/15 by Csilla Uličná, Csilla Ulicna, Ulicna, Csilla +3
Biochemistry, Genetics and Molecular Biology · #Bacterial Genetics and Biotechnology #Cell death mechanisms and regulation #FOS: Biological sciences #Gene Regulatory Network Analysis #Molecular Networks (q-bio.MN) #q-bio.MN
paper · pdf · doi:10.48550/arxiv.1301.3318
arxiv created 2013/01/15 · openalex publication_date 2013/01/15 · arxiv updated 2013/01/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
The TNF initiated processes are simulated using our integrative computational model with new quantitative proteomics data obtained on HeLa cell line. In spite of fact, that the model development is based on limited experimental information, with missing data estimated by simulations and parametrization using indirect experiments on different cell lines, the actual model with HeLa experimental data provides pleasant agreement between the computationally predicted behavior and experiments. Since no significant departures from experimentally determined functionality of HeLa cells has been observed, this can be taken as encouraging sign, that substantial features of the cell line behavior are reproduced correctly and indicate new possibilities for cell-line specific computational experiments.