2003/11/25 by Rodrick Wallace, Wallace, Rodrick, Deborah Wallace +3
Biochemistry, Genetics and Molecular Biology · #FOS: Biological sciences #Neurons and Cognition (q-bio.NC) #Tissues and Organs (q-bio.TO) #q-bio.NC #q-bio.TO
paper · pdf · doi:10.48550/arxiv.q-bio/0311034
10 pages, 1 figure. In press, J. Nat. Med. Assn
arxiv created 2003/11/25 · arxiv updated 2009/12/01
We suggest that a particular form of social hierarchy, which we characterize as 'pathogenic', can, from the earliest stages of life, exert a formal analog to evolutionary selection pressure, literally writing a permanent developmental image of itself upon immune function as chronic vascular inflammation and its consequences. The staged nature of resulting disease emerges 'naturally' as a rough analog to punctuated equilibrium in evolutionary theory, although selection pressure is a passive filter rather than an active agent like structured psychosocial stress. Exposure differs according to the social constructs of race, class, and ethnicity, accounting in large measure for observed population-level differences in rates of coronary heart disease across industrialized societies. American Apartheid, which enmeshes both majority and minority communities in a social construct of pathogenic hierarchy, appears to present a severe biological limit to continuing declines in coronary heart disease for powerful as well as subordinate subgroups: 'Culture', to use the words of the evolutionary anthropologist Robert Boyd, 'is as much a part of human biology as the enamel on our teeth'.