Functional mechanisms of neurotransmitter transporters regulated by lipid–protein interactions of their terminal loops

2015/04/09 by George Khelashvili, Harel Weinstein · 13 citations
Neuroscience · Biochemistry, Genetics and Molecular Biology · #Neuroscience and Neuropharmacology Research #Receptor Mechanisms and Signaling #Lipid Membrane Structure and Behavior

paper · doi:10.1016/j.bbamem.2015.03.025

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• Emerging Diversity in Lipid–Protein Interactions
• Lipids modulate the conformational dynamics of a secondary multidrug transporter. [europepmc]
• Phosphorylation mechanisms in dopamine transporter regulation. [europepmc]
• Mapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular Dynamics. [europepmc]
• Phosphorylation of the Amino Terminus of the Dopamine Transporter: Regulatory Mechanisms and Implications for Amphetamine Action. [europepmc]
• How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties. [europepmc]
• Thermostabilization and purification of the human dopamine transporter (hDAT) in an inhibitor and allosteric ligand bound conformation. [europepmc]
• Emerging Diversity in Lipid-Protein Interactions. [europepmc]
• Insights into the mechanism and pharmacology of neurotransmitter sodium symporters. [europepmc]
• Cell-Free Expression to Probe Co-Translational Insertion of an Alpha Helical Membrane Protein. [europepmc]
• Targeting SLC transporters: small molecules as modulators and therapeutic opportunities. [europepmc]
• Dopamine transporter membrane mobility is bidirectionally regulated by phosphorylation and palmitoylation. [europepmc]
• The tether function of the anoctamins. [europepmc]