Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines

2001/10/01 by Osamu Yanagida, Yoshikatsu Kanai, Arthit Chairoungdua +20 · 31 citations
Biochemistry, Genetics and Molecular Biology · #Amino Acid Enzymes and Metabolism #Epigenetics and DNA Methylation #Metabolism and Genetic Disorders

paper · doi:10.1016/s0005-2736(01)00384-4

Cited by

• BNCT pancreatic cancer treatment strategy with glucose-conjugated boron drug
• The Ketogenic Diet and Brain Metabolism of Amino Acids: Relationship to the Anticonvulsant Effect
• Characteristics of 18F-FDG and 18F-FDOPA PET in an 8-year-old neutered male Yorkshire Terrier dog with glioma: long-term chemotherapy using hydroxyurea plus imatinib with prednisolone and immunoreactivity for PDGFR-β and LAT1
• A genome wide CRISPR screen reveals novel determinants of long-lived plasma cell secretory capacity
• Extracellular vesicle cargo from lipofibroblasts mitigates chronic obstructive pulmonary disease by alveolar type 2 cell restoration
• The SLC3 and SLC7 families of amino acid transporters
• The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect. [europepmc]
• Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle. [europepmc]
• The methylmercury-L-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter. [europepmc]
• Bidirectional transport of amino acids regulates mTOR and autophagy. [europepmc]
• Structure and mechanism of a Na+-independent amino acid transporter. [europepmc]
• Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1. [europepmc]
• Metabolic positron emission tomography imaging in cancer detection and therapy response. [europepmc]
• Relation of LAT1/4F2hc expression with pathological grade, proliferation and angiogenesis in human gliomas. [europepmc]
• Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer. [europepmc]
• The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation. [europepmc]
• Brain interstitial fluid glutamine homeostasis is controlled by blood-brain barrier SLC7A5/LAT1 amino acid transporter. [europepmc]
• The Emerging Hallmarks of Cancer Metabolism. [europepmc]
• The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5). [europepmc]
• Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte/Macrophage Immune Responses. [europepmc]
• Transporter-Guided Delivery of Nanoparticles to Improve Drug Permeation across Cellular Barriers and Drug Exposure to Selective Cell Types. [europepmc]
• Amino Acid Transporters and Glutamine Metabolism in Breast Cancer. [europepmc]
• The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours. [europepmc]
• The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health. [europepmc]
• The L-Type Amino Acid Transporter LAT1-An Emerging Target in Cancer. [europepmc]
• Amino acids in cancer. [europepmc]
• Poly(vinyl alcohol) boosting therapeutic potential of p -boronophenylalanine in neutron capture therapy by modulating metabolism. [europepmc]
• L-Type amino acid transporter 1 as a target for drug delivery. [europepmc]
• Regulation of mTORC1 by Upstream Stimuli. [europepmc]
• Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance. [europepmc]
• Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart. [europepmc]