2024/12/04 by Ragni, Alessandra, Martinussen, Torben, Scheike, Thomas
#Applications (stat.AP) #FOS: Computer and information sciences #Methodology (stat.ME)
paper · doi:10.48550/arxiv.2412.03246
In clinical trials with recurrent events, such as repeated hospitalizations terminating with death, it is important to consider the patient events overall history for a thorough assessment of treatment effects. The occurrence of fewer events due to early deaths can lead to misinterpretation, emphasizing the importance of a while-alive strategy as suggested in Schmidli et al. (2023). In this study, we focus on the patient weighted while-alive estimand, represented as the expected number of events divided by the time alive within a target window, and develop efficient estimation for this estimand. Specifically, we derive the corresponding efficient influence function and develop a one-step estimator initially applied to the simpler irreversible illness-death model. For the broader context of recurrent events, due to the increased complexity, this one-step estimator is practically intractable due to likely misspecification of the needed conditional transition intensities that depend on a patient's unique history. Therefore, we suggest an alternative estimator that is expected to have high efficiency, focusing on the randomized treatment setting. Additionally, we apply our proposed estimator to two real-world case studies, demonstrating the practical applicability of this second estimator and benefits of this while-alive approach over currently available alternatives.