PDLIM3 expression is implicated in the invasive behavior of glioblastoma stem cells and their ability to form neurospheres.

2025/01/01 by Yvan Nicaise, Caroline Delmas, É. Cohen-Jonathan-Moyal +1
Medicine · #Chemokine receptors and signaling #Glioma Diagnosis and Treatment #Neuroblastoma Research and Treatments

paper · doi:10.17912/micropub.biology.001613

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22

Abstract

The recurrence of glioblastoma can be attributed to the high invasiveness and resistance of glioblastoma stem cells (GSCs). Therefore, it is crucial to investigate the molecular mechanisms that drive the agressiveness of these cells. This research focuses on the actin-associated protein PDLIM3 that we found overexpressed in GBM and in highly invasive GSCs. Suppressing PDLIM3 expression with targeted siRNAs significantly decreases cell invasion. Additionally, our findings highlight that PDLIM3 is essential for GSCs in forming neurospheres. This research provides the first evidence that PDLIM3 may contribute to the aggressiveness of glioblastoma by facilitating GSCs sphere formation and enhancing their invasiveness.

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