2020/01/22 by Elisenda Feliu, Feliu, E., Nidhi Kaihnsa +5 · 2 citations
Biochemistry, Genetics and Molecular Biology · #Algebraic Geometry (math.AG) #Dynamical Systems (math.DS) #FOS: Biological sciences #FOS: Mathematics #Gene Regulatory Network Analysis #Microtubule and mitosis dynamics #Molecular Networks (q-bio.MN) #Protein Structure and Dynamics
paper · pdf · doi:10.48550/arxiv.2001.08285
openalex publication_date 2020/01/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Multistationarity in molecular systems underlies switch-like responses in cellular decision making. Determining whether and when a system displays multistationarity is in general a difficult problem. In this work we completely determine the set of kinetic parameters that enable multistationarity in a ubiquitous motif involved in cell signaling, namely a dual phosphorylation cycle. In addition we show that the regions of multistationarity and monostationarity are both path connected. We model the dynamics of the concentrations of the proteins over time by means of a parametrized polynomial ordinary differential equation (ODE) system arising from the mass-action assumption. Since this system has three linear first integrals defined by the total amounts of the substrate and the two enzymes, we study for what parameter values the ODE system has at least two positive steady states after suitably choosing the total amounts. We employ a suite of techniques from (real) algebraic geometry, which in particular concern the study of the signs of a multivariate polynomial over the positive orthant and sums of nonnegative circuit polynomials.