2021/08/31 by Orso Pusterla, Rahel Heule, Pusterla, Orso +19
Medicine · #COVID-19 diagnosis using AI #FOS: Electrical engineering #FOS: Physical sciences #Image and Video Processing (eess.IV) #Lung Cancer Diagnosis and Treatment #Medical Physics (physics.med-ph) #Radiomics and Machine Learning in Medical Imaging #electronic engineering #information engineering
paper · pdf · doi:10.48550/arxiv.2108.13754
openalex publication_date 2021/08/31 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Purpose: To introduce a widely applicable workflow for pulmonary lobe segmentation of MR images using a recurrent neural network (RNN) trained with chest computed tomography (CT) datasets. The feasibility is demonstrated for 2D coronal ultra-fast balanced steady-state free precession (ufSSFP) MRI. Methods: Lung lobes of 250 publicly accessible CT datasets of adults were segmented with an open-source CT-specific algorithm. To match 2D ufSSFP MRI data of pediatric patients, both CT data and segmentations were translated into pseudo-MR images, masked to suppress anatomy outside the lung. Network-1 was trained with pseudo-MR images and lobe segmentations, and applied to 1000 masked ufSSFP images to predict lobe segmentations. These outputs were directly used as targets to train Network-2 and Network-3 with non-masked ufSSFP data as inputs, and an additional whole-lung mask as input for Network-2. Network predictions were compared to reference manual lobe segmentations of ufSSFP data in twenty pediatric cystic fibrosis patients. Manual lobe segmentations were performed by splitting available whole-lung segmentations into lobes. Results: Network-1 was able to segment the lobes of ufSSFP images, and Network-2 and Network-3 further increased segmentation accuracy and robustness. The average all-lobe Dice similarity coefficients were 95.0±2.8 (mean±pooled SD [%]), 96.4±2.0, 93.0±2.0, and the average median Hausdorff distances were 6.1±0.9 (mean±SD [mm]), 5.3±1.1, 7.1±1.3, for Network-1, Network-2, and Network-3, respectively. Conclusions: RNN lung lobe segmentation of 2D ufSSFP imaging is feasible, in good agreement with manual segmentations. The proposed workflow might provide access to automated lobe segmentations for various lung MRI examinations and quantitative analyses.