Synthetic pathways and processes for effective production of 5-hydroxytryptophan and serotonin from glucose in Escherichia coli

2019/03/19 by Mora Villalobos, José Aníbal, Zeng, An-Ping
#5-hydroxytryptophan #Aromatic amino acid hydroxylase #Biologie #Biowissenschaften #Ingenieurwissenschaften #Protein engineering #Serotonin #Synthetic pathway

paper · doi:10.15480/882.2123

Abstract

Tryptophan derivatives such as 5-hydroxytryptophan (5HTP) and serotonin are valuable molecules with pharmaceutical interest. 5HTP is presently mainly obtained by extraction from the plant Griffonia simplicifolia and serotonin is produced by chemical synthesis. A simple biotechnological method for the production of these compounds is desired.

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