2004/05/31 by Luciano da Fontoura Costa, Costa, Luciano da Fontoura
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Bioinformatics and Genomic Networks #Disordered Systems and Neural Networks (cond-mat.dis-nn) #FOS: Biological sciences #FOS: Physical sciences #Molecular Networks (q-bio.MN) #cond-mat.dis-nn #q-bio.MN
paper · pdf · doi:10.48550/arxiv.q-bio/0405028
4 pages, 1 figure
arxiv created 2004/05/31 · openalex publication_date 2004/05/31 · arxiv updated 2009/12/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/28
Recent developments in complex networks have paved the way to a series of important biological insights, such as the fact that many of the essential proteins of S. cerevisae corresponds to the so-called hubs of the respective protein-protein interaction networks. Despite the special importance of hubs, other types of nodes such as those corresponding to the network border, as well as the innermost nodes, also deserve special attention. This work reports on how the application of the concept of distance transform to networks showed that a great deal of the innermost nodes correspond to essential proteins, with interesting biological implications.