Multiple System Organ Failure

1980/02/01 by Donald E. Fry · 27 citations
Medicine · Engineering · #Cardiac Arrest and Resuscitation #Respiratory Support and Mechanisms #Mechanical Circulatory Support Devices

paper · doi:10.1001/archsurg.1980.01380020006003

Abstract

Multiple system organ failure (MSOF) remains a principal cause of death after major operative procedures and/or severe trauma. We studied multiple parameters in 553 consecutive emergency surgical patients to determine the incidence of MSOF, the predisposing factors to MSOF, and the sequelae of MSOF. Thirty-eight patients had MSOF; mortality was 74% for these patients. Evaluation of multiple factors demonstrated that (1) MSOF is primarily due to infection, (2) the temporal sequence of organ failure is lung, liver, gastric mucosa, and kidney, and (3) MSOF is the most common fatal expression of uncontrolled infection.

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