2024/12/19 by Sukanta Mukherjee, Enrico Skoruppa, Mukherjee, Sukanta +7
Computer Science · Engineering · #Biological Physics (physics.bio-ph) #Cellular Automata and Applications #FOS: Physical sciences #Modular Robots and Swarm Intelligence
paper · pdf · doi:10.48550/arxiv.2412.15394
openalex publication_date 2024/12/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Epigenetic inheritance during cell division is essential for preserving cell identity by stabilizing the overall chromatin organisation. Heterochromatin,the condensed and transcriptionally silent fraction of chromatin,is marked by specific epigenetic modifications that are diluted during each cell division. Here we build a physical model,based on the formation of a biomolecular condensate,a liquid 'droplet',that promotes the restoration of epigenetic marks. Heterochromatin facilitates the droplet formation via polymer-assisted condensation(PAC). The resulting condensate serves as a reaction chamber to reconstruct the lost epigenetic marks. We incorporate the enzymatic reactions into a particle-based simulation and monitor the progress of the epigenetic markers through an in silico analogue of the cell cycle. We demonstrate that the proposed mechanism is robust and stabilizes the heterochromatin domains over many cell generations. This mechanism and variations thereof might be at work for other epigenetic marks as well.