An Integrated Approach to Diabetic Retinopathy Research

2011/02/14 by Thomas W. Gardner · 102 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · Psychology · #Bioinformatics #Diabetes mellitus #Diabetic retinopathy #Endocrinology #Internal medicine #Medicine #Neuroscience #Ophthalmology #Optometry #Pathophysiology #Psychology #Retina #Retinal #Retinal Development and Disorders #Retinal Diseases and Treatments #Retinal Imaging and Analysis #Retinopathy

paper · open access · doi:10.1001/archophthalmol.2010.362

published in Archives of Ophthalmology 129(2), 230 (American Medical Association)

openalex publication_date 2011/02/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25

Abstract

This review discusses the pathophysiology of diabetic retinopathy related to direct effects of loss of insulin receptor action and metabolic dysregulation on the retina. The resulting sensory neuropathy can be diagnosed by structural and functional tests in patients with mild nonproliferative diabetic retinopathy. Research teams can collaborate to integrate ocular and systemic factors that impair vision and to design strategies to maintain retinal function in persons with diabetes mellitus. Evolving concepts may lead to inclusion of tests of retinal function in the detection of diabetic retinopathy and neuroprotective strategies to preserve vision for persons with diabetes.

Citations

• Projection of Diabetic Retinopathy and Other Major Eye Diseases Among People With Diabetes Mellitus
• Microglial Activation in Human Diabetic Retinopathy

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• Retinal Neurodegeneration in db/db Mice at the Early Period of Diabetes. [europepmc]
• Enhanced Oxidative Stress and Other Potential Biomarkers for Retinopathy in Type 2 Diabetics: Beneficial Effects of the Nutraceutic Supplements. [europepmc]
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• The Relationship between Nonalcoholic Fatty Liver Disease and Retinopathy in NHANES III. [europepmc]
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• Association of non-alcoholic fatty liver disease with diabetic retinopathy in type 2 diabetic patients: A meta-analysis of observational studies. [europepmc]
• The neuroscience of diabetic retinopathy. [europepmc]
• Current understanding of the molecular and cellular pathology of diabetic retinopathy. [europepmc]
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• Beyond the Liver: Liver-Eye Communication in Clinical and Experimental Aspects. [europepmc]
• In Vivo Capillary Structure and Blood Cell Flux in the Normal and Diabetic Mouse Eye. [europepmc]
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• Retinal Vascular Lesions in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. [europepmc]
• Deciphering the Connection Between Microvascular Damage and Neurodegeneration in Early Diabetic Retinopathy. [europepmc]

Related

• Pathophysiology and Pathogenesis of Diabetic Retinopathy (revision number 14)
• Diabetic retinopathy: New concepts of screening, monitoring, and interventions
• Pathophysiology of Diabetic Retinopathy
• Diabetic Retinopathy Viewed as a Neurosensory Disorder
• Diabetic Retinopathy: A Position Statement by the American Diabetes Association