2023/05/12 by Arshad, Adina, Z. Qadeer, Irfan, Muhammad +1
#Medicine and Health Sciences
paper · doi:10.17605/osf.io/ykjex
During spermiogenesis, sperm chromatin undergoes a series of modifications in which histones are lost and replaced with transition nuclear proteins (TNP) and subsequently with protamine. Histones are important for DNA replication but in spermiogenesis histones replacement with protamine prevents DNA replication and causes sperm maturation. Any problem in this replacement may cause male infertility. Few molecular epidemiological studies have been conducted to examine the association between TNP2 polymorphism and male infertility in diverse populations. These studies to date have analyzed the above polymorphisms in small sample sizes, leading to an underestimation of the association. There is no meta-analysis exploring the exact association between the TNP SNPs and male infertility reported so far.